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[Changes in the immunologic competence of patients with stable hyperthyroidism after successful therapy with 131I].
The alterations in cell-mediated immunity (CMI) were assessed by means of testing T lymphocyte blast transformation induced by mitogens (phytohaemagglutinin, PHA, and concanavalin A, Con A), and by measuring natural killer activity in the peripheral blood of 36 patients with mild hyperthyroidism and 18 healthy subjects. The subjects were reassessed 1, 3 and 6 months after 131I treatment and during maintenance radioiodine therapy. Fourteen patients who had been taking thyroxine (T4) for > or = 3 months were included in the study group. The number of CMI tests and the number of T4-treated patients in whom decreased T4 serum concentrations were observed were significantly increased, as were the WBC counts. There were no significant differences in the T cell response and the natural killer activity among the healthy subjects and hyperthyroid patients. While T4-treated patients showed an increased proportion of Ly2, and a decreased proportion of Ly3 in the helper/inducer (T4) lymphocytes, there was no significant alteration in the proportion of these subpopulations in the controls. The number of CMI tests, the proportion of Ly2, and the serum level of T4 correlated with the serum TSH level (r = 0.521, r = -0.634, and r = 0.547, respectively). The ratio of natural killer cells against tumour target K562 and lymphoma target K562/ADCC-ms did not change significantly. Even after cessation of T4 treatment, the proportion of Ly2 was still higher than in the controls (p 2011 Ford Escape for Sale in AZ — Used $7,450

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