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Interaction of presbyopia-related genes with lifestyle factors and environmental factors in shaping the refractive phenotype.
The prevalence and onset of presbyopia are increasing worldwide. Genetic studies have implicated several loci in the etiology of presbyopia. To examine the genetic contribution to refractive errors, the study included 3 groups of individuals: (1) individuals with myopia (N = 498); (2) individuals with emmetropia (N = 618); and (3) individuals with hyperopia (N = 413). In all, 40 single nucleotide polymorphisms (SNPs) previously reported to be associated with presbyopia were selected. Allele frequencies were estimated and linkage disequilibrium (LD) patterns for the SNPs examined. Generalized multifactor dimensionality reduction was used to explore the association of the polymorphisms and refraction with lifestyle factors and environmental factors. The linear mixed model was used to estimate the effect of each SNP and haplotype on refraction. The most significant SNP for myopia was rs4733796. Other significant SNPs that were common in at least 2 refraction groups were 1 in the emmetropia group (rs10865331), 2 in the hyperopia group (rs4733796, rs908845), and 3 in the emmetropia group (rs217185, rs10865331, and rs908845). The haplotypes included the 6 most significant SNPs from a total of 10 SNPs in the emmetropia group. The multivariate analyses revealed a significant effect of lifestyle factors such as time spent outdoors, number of TV hours, and time on computers on refraction. Overall, lifestyle factors, together with environmental factors, have significant effects on refraction.[Radiotherapy of the connective tissue diseases].
Radiotherapy of different connective tissue diseases is reviewed. A larger fractionation schedule induces complete and partial
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